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Welcome to NEXLETOL!

NEXLETOL is a once-daily, nonstatin pill for adults. It is used to help lower your bad cholesterol (LDL-C) when you add it to a healthy diet and other lipid-lowering medicines.

NEXLETOL is for adults who have:

  • heterozygous familial hypercholesterolemia (an inherited condition that causes high levels of bad cholesterol) and/or
  • known cardiovascular disease due to high levels of bad cholesterol

It is not known if NEXLETOL can decrease problems related to high cholesterol, such as heart attacks or stroke.

Tell your doctor if you are taking simvastatin or pravastatin. Your dose for these medicines may need to be lowered while taking NEXLETOL.

Please carefully read the Important Safety Information below.

LDL-C=low-density lipoprotein cholesterol.

Questions about NEXLETOL? Call 1-833-377-7633



NEXLETOL is a prescription medicine used, along with diet and other lipid-lowering medicines, in the treatment of adults who need additional lowering of “bad” cholesterol (LDL-C) and have:

  • heterozygous familial hypercholesterolemia (HeFH), an inherited condition that causes high levels of LDL-C, and/or
  • known cardiovascular disease

It is not known if NEXLETOL can decrease problems related to high cholesterol, such as heart attacks or stroke.


What should I tell my doctor before taking NEXLETOL?

Tell your doctor if you:

  • have, or have ever had, gout
  • have, or have ever had, tendon problems
  • are pregnant or breastfeeding, or may become pregnant or plan to breastfeed
  • have severe kidney or liver problems
  • are taking simvastatin or pravastatin

What is the most important safety information I should know about NEXLETOL?

NEXLETOL can cause side effects that can become serious, including:

  • high levels of uric acid in the blood, which can lead to gout, a painful joint condition
  • severe tendon injury, most often in the bicep tendon, Achilles tendon, or rotator cuff (shoulder)

What are the common side effects of NEXLETOL?

Tell your doctor right away about any side effect you experience. NEXLETOL can cause side effects, including:

  • symptoms of the common cold or flu
  • muscle spasms
  • back pain
  • pain in the legs or arms
  • stomach pain

Your doctor may check your blood for side effects that you might not be able to feel.

These are not all the possible side effects of NEXLETOL. For more information, ask your doctor or pharmacist.

What form does NEXLETOL come in?

NEXLETOL is a tablet that you take by mouth. It contains 180 mg of bempedoic acid.

Can I take NEXLETOL with other medicines?

For lowering cholesterol, NEXLETOL is often taken with other medicines, including a group of medicines called statins. For two statins, simvastatin and pravastatin, your doctor may change the dose if you also take NEXLETOL. Before taking NEXLETOL, tell your doctor if you take any of the following medicines:

  • simvastatin
  • pravastatin

The risk information provided here is not comprehensive. To learn more, talk about NEXLETOL with your doctor or pharmacist. The FDA-approved product labelling can be found at NEXLETOL.com or 1-833-377-7633.

You may report side effects to the FDA at 1-800-FDA-1088, or at www.fda.gov/medwatch. You may also report side effects to ESPERION at 1-833-377-7633.

NEXLETOL is available by prescription only.

Please see full Prescribing Information, including Patient Product Information.